By Andrew D Shaw; et al
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Extra info for Acute care of the cancer patient
These data strongly suggested that optimal combination therapy occurred in tumors that were positive for the respective growth factor receptors and secreted the ligand (which upregulated the receptor on tumor-associated endothelium, thus being vulnerable to TKI-mediated apoptosis). This dual targeting is not limited to EGF-R inhibition. C. Blockade of Vascular Endothelial Growth Factor Receptor Signaling Using a mouse-speciﬁc antibody (DC101) against the VEGF receptor, Bruns et al. (89) demonstrated inhibition of tumor growth, decrease in metastasis, and induction of apoptosis in both tumor cells and the tumor-associated endothelium in the human 5 pancreatic tumor model in nude mice.
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78. Christodoulou C, Klouvas G, Pateli A, Mellou S, Sgouros J, Skarlos DV. Prolonged administration of weekly paclitaxel and trastuzumab in patients with advanced breast cancer. Anticancer Res 2003; 23: 737–744. 79. Herbst RS, Hong WK. IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer. Semin Oncol 2002; 29: 18–30. 80. Peggs K, Mackinnon S. Imatinib mesylate—the new gold standard for treatment of chronic myeloid leukemia. New Engl J Med 2003; 348:1048–1050.