By Lena M. Napolitano MD, Krishnan Raghavendran MD

This factor of severe Care Clinics will specialize in critical Acute respiration misery Syndrome and working with it within the ICU. issues will contain: demanding situations and Successes in ARDS Research;Mechanical air flow with Lung protecting innovations: What works?; Gene treatment for ALI/ARDS;High Frequency Oscillatory air flow in ALI/ARDS;Prone positioning treatment in ARDS;Recovery and long term consequence in ARDS; and Experimental versions and emergeing hypotheses for ALI and ARDS

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Additional resources for ALI and ARDS: Challenges and Advances, An Issue of Critical Care Clinics (The Clinics: Internal Medicine)

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5. The opening procedure for collapsed lungs. ) mark the treat ment goal of each specific intervention. The non italic words mark the achieved state of the lung. At the beginning, the precise amount of collapsed lung tissue is not known. (Reprin ted from Lachmann B. Open lung in ARDS. 25 Various methods to open the lung have been reported. 34 Once the RM is accomplished, optimal PEEP is determined by incrementally reducing PEEP while monitoring for a reduction in Cdyn or oxygenation to suggest lung unit collapse and identify the closing pressure.

Randomized, placebo-controlled clinical trial of an aerosolized beta-2 agonist for treatment of acute lung injury. Am J Respir Crit Care Med 2011. [Epub ahead of print]. Mechanical Ven t i l a t i o n w i t h L u n g P ro t e c t i v e S t r a t e g i e s : W h a t Wor k s ? Carl F. Haas, MLS, RRT KEYWORDS  Lung protective ventilation  Positive end-expiratory pressure  Recruitment maneuver Essentially all patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) require mechanical ventilatory assistance to support gas exchange and reduce the work of breathing associated with the lung impairment.

Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome. A randomized controlled trial. JAMA 2000;283:1995–2002. 2. ARDS Clinical Trials Network. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342:1301–8. 3. Steinberg KP, Hudson LD, Goodman RB, et al; NIH/NHLBI ARDSNet. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome.

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