By Jean-Louis Vincent (Ed.), Jean-Louis Vincent

The Yearbook compiles the newest advancements in experimental and scientific learn and perform in a single complete reference ebook. The chapters are written via good well-known specialists within the box of in depth care and emergency medication. it's addressed to each person fascinated with inner drugs, anesthesia, surgical procedure, pediatrics, in depth care and emergency medicine.

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Extra resources for Annual Update in Intensive Care and Emergency Medicine 2014

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28 L. T. van Eijk et al. Conclusion Profound changes in iron metabolism occur in critically ill patients. These changes are predominantly the result of both blood loss and the inflammatory process, and are relevant to the intensive care patient for three reasons: 1) anemia is frequently observed in critically ill patients, is associated with impaired immunity and worse outcome, and cannot be adequately compensated by transfusions or erythropoiesis – stimulating agents, whereas there might be an additive role for iron supplementation; 2) iron homeostasis may determine the fate of an infection, as iron is an essential nutrient for pathogens, and future research should, therefore, clarify the exact role of bound and unbound iron in critically ill infected patients; 3) iron can catalyze oxidative stress reactions that cause organ damage, especially when non-transferrin-bound or labile iron exists.

Crit Care Med 27:2630–2639 39. Reggiori G, Occhipinti G, De Gasperi A, Vincent JL, Piagnerelli M (2009) Early alterations of red blood cell rheology in critically ill patients. Crit Care Med 37:3041–3046 40. Rice L, Alfrey CP (2005) The negative regulation of red cell mass by neocytolysis: physiologic and pathophysiologic manifestations. Cell Physiol Biochem 15:245–250 41. Weiss G, Goodnough LT (2005) Anemia of chronic disease. N Engl J Med 352:1011–1023 42. van Eijk LT, Kroot JJ, van der Hoeven JG, Swinkels DW, Pickkers P (2011) Inflammationinduced hepcidin-25 is associated with the development of anemia in septic patients: an observational study.

Clin Exp Immunol 126:466–473 29. Melo RA, Garcia AB, Viana SR, Falcão RP (1997) Lymphocyte subsets in experimental hemochromatosis. Acta Haematol 98:72–75 30. Gutteridge JM (1986) Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides. FEBS Lett 201:291–295 31. Hampton MB, Kettle AJ, Winterbourn CC (1998) Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood 92:3007–3017 32. Haase M, Bellomo R, Haase-Fielitz A (2010) Novel biomarkers, oxidative stress, and the role of labile iron toxicity in cardiopulmonary bypass-associated acute kidney injury.

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